On October 23, 2015, the CHMP gave new advice for doctors and patients in order to minimize the risk of progressive multifocal leukoencephalopathy ("PML") in patients treated with the multiple sclerosis medicine Tecfidera ("dimethyl fumarate"). PML is a rare brain infection caused by the John Cunningham virus. EMA has recommended that a complete blood count should be performed before starting treatment with Tecfidera and every three months during treatment. Additionally, a baseline MRI should be available as a reference (usually within three months).
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